The Investigation of Cinnamon Leaf Oil Nanocream for Antimicrobial and Skin Irritation

  • Nor Azah Zainol MARA Higher Vocational College, Mukim Durian Pipit, 33400 Lenggong, Perak, Malaysia
  • Yusrida Darwis Discipline of Pharmaceutical Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia.
  • Nor Asfaliza Abdullah Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Jeli Campus, 17600 Jeli, Kelantan, Malaysia.
Keywords: Cinnamon leaf oil, Nanocream, Antimicrobial, Primary skin irritation

Abstract

Cinnamon leaf oil contains a high amount of eugenol which has been reported to have antimicrobial activity. The aims of this study were to test the antimicrobial and primary skin irritation activities of 2% cinnamon leaf oil nanocream. The antimicrobial activity of the nanocream was tested in vitro against different gram positive and gram negative bacterial strains whereas primary skin irritation activity was studied in vivo using New Zealand White rabbits. The microbiological test revealed that the 2% cinnamon leaf oil nanocream inhibited the growth of gram positive (Methicillin-sensitive Staphylococcus aureous, Methicilline-resistant Staphylococcus aureus and Bacillus subtilis) and gram negative bacteria (Klebsiella pneumonia, and Escherichia coli) except Pseudomonas aeruginosa. Moreover, the irritation test showed  that the nanocream was non-irritant. Therefore, the results of the present study suggested that the 2% cinnamon leaf oil nanocream has great potential to be used as a topical antiseptic and not give any irritant to the people

Published
2020-03-01
How to Cite
Zainol, N. A., Darwis, Y., & Abdullah, N. A. (2020). The Investigation of Cinnamon Leaf Oil Nanocream for Antimicrobial and Skin Irritation . SA Conference Series: Industrial Revolution 4.0, 1(1), 29-37. Retrieved from https://conference.scientiaca.org/index.php/ir4/article/view/5
Section
Articles