The Investigation of Cinnamon Leaf Oil Nanocream for Antimicrobial and Skin Irritation
Cinnamon leaf oil contains a high amount of eugenol which has been reported to have antimicrobial activity. The aims of this study were to test the antimicrobial and primary skin irritation activities of 2% cinnamon leaf oil nanocream. The antimicrobial activity of the nanocream was tested in vitro against different gram positive and gram negative bacterial strains whereas primary skin irritation activity was studied in vivo using New Zealand White rabbits. The microbiological test revealed that the 2% cinnamon leaf oil nanocream inhibited the growth of gram positive (Methicillin-sensitive Staphylococcus aureous, Methicilline-resistant Staphylococcus aureus and Bacillus subtilis) and gram negative bacteria (Klebsiella pneumonia, and Escherichia coli) except Pseudomonas aeruginosa. Moreover, the irritation test showed that the nanocream was non-irritant. Therefore, the results of the present study suggested that the 2% cinnamon leaf oil nanocream has great potential to be used as a topical antiseptic and not give any irritant to the people
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